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With Juve competing on three fronts this season, Allegri is likely to make several changes to refresh his starting XI, meaning Pogba is set to be left out for the quarter-final tie at the Stadio Olimpico.
The changes mean midfielder Hernanes is set to come in to face his former club while Simone Zaza will also get a chance in attack.
"Wednesday's line-up will be the best I can pick for the game," Allegri said at Tuesday's news conference. "We have many matches to play in a short space of time.
"We'll play a decent line-up in order to try and get through to the next round.
"Hernanes will replace Claudio Marchisio in theory. As for Leonardo Bonucci and Giorgio Chiellini, I will see.
"Paul Pogba has played in practically all of our games so far. Kwadwo Asamoah did well on Sunday [a 4-0 win over Udinese] and came through unscathed.
"The team has given no signs of weakness, even with many changes. On Wednesday, the best team will go out onto the pitch, also with Sunday's game against Roma in mind."
Juve have enjoyed a resurgence in Serie A in recent weeks, moving up to second place, two points behind leaders Napoli.
And with a Champions League clash with Bayern Munich looming large, it would be easy for the Bianconeri squad to lose focus, something Allegri is determined will not happen.
He added: "We're still in the running on three fronts but haven't achieved anything. We must keep working and picking up points."
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