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Marcel Schmelzer is also feeling unwell and is unlikely to feature at Signal Iduna Park.
Dortmund can draw within five points of Bundesliga leaders Bayern Munich with a victory, with Pep Guardiola's side in action on Sunday against Hoffenheim.
"Ilkay Gundogan and Marco Reus have caught a virus and we will have to wait on how that pans out," Dortmund head coach Thomas Tuchel told reporters.
"Marcel Schmelzer is not feeling well either, so we might be without him as well. Erik Durm on the other hand is raring to go again and is a candidate to start."
Reus paid former Bayern doctor Hans-Wilhelm Muller-Wohlfahrt a visit in midweek to have an adductor injury looked at, but Tuchel insists there are no new concerns over the winger's fitness.
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